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Epidermal nevi with aberrant epidermal structure in keratinocytes and melanocytes
Author(s) -
Oiso Naoki,
Sugawara Koji,
Yonamine Ayano,
Tsuruta Daisuke,
Kawada Akira
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12787
Subject(s) - ultrastructure , pathology , nevus , biology , dermatology , medicine , genetics , melanoma
Abstract Epidermal nevi are congenital cutaneous hamartomas caused by embryonic somatic mutations. Ultrastructural features of adult epidermal nevi have rarely been investigated. Herein, we report a case involving a Japanese adult who had epidermal nevi with right congenital blindness and a right accessory nipple. The histopathologic and ultrastructural studies showed divergent abnormal epidermal structures in both melanocytes and keratinocytes. Our case indicates the need to further investigate histopathologic, ultrastructural, and genetic associations in adult epidermal nevi.