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Case series of patients with chronic foot ulcers treated with autologous platelet‐rich plasma
Author(s) -
Yotsu Rie R.,
Hagiwara Shotaro,
Okochi Hitoshi,
Tamaki Takeshi
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12777
Subject(s) - medicine , platelet rich plasma , diabetes mellitus , platelet , fibrin , peripheral , arterial disease , diabetic foot , chronic wound , polyarteritis nodosa , wound healing , surgery , disease , gastroenterology , vascular disease , immunology , vasculitis , endocrinology
Treatment for patients with chronic wounds is entering a new era, and autologous platelet‐rich plasma ( PRP ) is among the most promising treatments. PRP contains a concentration of platelets obtained by centrifuging the patient's blood. Because it contains fibrin and high concentrations of growth factors, PRP is known to promote wound healing. In this study, we present five patients with chronic foot ulcers successfully treated with PRP in our institution. The patients had various underlying diseases: diabetes ( n = 2), peripheral arterial disease ( n = 1), both diabetes and peripheral arterial disease ( n = 1) , and cutaneous polyarteritis nodosa ( n = 1). Also, we provide a description of PRP 's mechanisms, advantages, and limitations.