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Variants in SELL , MRPS 36P2 , TP 63 , DDB 2 , CACNA 1H , ADAM 19 , GNAI 1 , CDH 13 and GABRG 2 interact to confer risk of acne in Chinese population
Author(s) -
Wang HongYan,
Guo MeiHua,
Shen SongKe,
He Li,
Zhang XueJun,
Zuo XianBo,
Yang Sen
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12754
Subject(s) - single nucleotide polymorphism , acne , snp , dbsnp , medicine , gene , genome wide association study , genetics , genetic association , biology , genotype , dermatology
Acne vulgaris is a common skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from androgen‐induced increased sebum production, altered keratinization, inflammation and bacterial colonization of hair follicles by propionibacterium acnes. Our previous genome‐wide association study on acne has identified two new susceptibility loci. To search for potential gene–gene interactions and investigate the best‐fit association models for the single nucleotide polymorphisms ( SNP ) from these interacting genes, we implemented logistic regression analysis in the combined sample of 2916 cases with severe acne and 4716 controls. The most significant association evidence was observed under an additive model for rs6896064 and under a dominant model the rest of these SNP . Significant interactions between these SNP were observed in this study: the SELL × MRPS 36P2 ( P adjusted = 4.15 × 10 −10 ), TP 63 × DDB 2 ( P adjusted = 7.62 × 10 −08 ), DDB 2 × CACNA 1H ( P adjusted = 1.89 × 10 −07 ), ADAM 19 × GNAI 1 × CDH 13 ( P adjusted = 1.22 × 10 −04 ) and ADAM 19 × GABRG 2 × GNAI 2 × CDH 13 ( P ad justed = 6.33 × 10 −05 ). These results may contribute to our understanding of acne genetic etiology and account for the additional risk of certain patients.