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Paraneoplastic pemphigus: Two cases of intra‐abdominal malignancy presenting solely as treatment refractory oral ulceration
Author(s) -
Kelly Shane,
Schifter Mark,
Fulcher David A.,
Lin MingWei
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12753
Subject(s) - paraneoplastic pemphigus , medicine , pemphigus vulgaris , malignancy , refractory (planetary science) , occult , dermatology , pemphigus , lymphoma , pathology , autoantibody , immunology , antibody , physics , alternative medicine , astrobiology
Two patients with initial diagnoses of oral lichen planus and pemphigus vulgaris presented with refractory oral mucosal blistering. Subsequent positive serology results for paraneoplastic pemphigus led to the discovery of occult intra‐abdominal malignancies in both, unicentric Castleman's and non‐ H odgkin's lymphoma. The diagnosis of paraneoplastic pemphigus should be considered in patients with recalcitrant oral ulceration, even in the absence of clinical features of malignancy.