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Demographic and clinical features of autoimmune thyroid disorder in J apanese patients with systemic sclerosis
Author(s) -
Toki Sayaka,
Motegi Seiichiro,
Yamada Kazuya,
Uchiyama Akihiko,
Ishikawa Osamu
Publication year - 2014
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12698
Subject(s) - medicine , thyroid , anti thyroid autoantibodies , autoantibody , thyroid peroxidase , autoimmune disease , disease , gastroenterology , antibody , immunology
Abstract Autoimmune thyroid disorders ( AITD ) are characterized by the impairment of the thyroid gland as a result of systemic or organ‐specific autoimmune disorders, and the presence of antithyroid autoantibodies, such as antithyroglobulin antibody ( A b T g) and antithyroid peroxidase antibody ( A b TPO ). Several studies have reported the association of AITD with systemic sclerosis ( SS c). However, none of those studies analyzed the association between AITD and skin sclerosis in SS c patients. The aim of this study was to examine the demographic and clinical features of SS c patients with AITD treated in our department. Of a total of 210 SS c patients, we identified 30 with AITD (14.3%), including 29 with H ashimoto's disease (13.8%) and one patient with G raves' disease (0.5%), indicating that hypothyroidism was more common among SS c patients with AITD . All patients with AITD were female, and anticentromere antibody positivity, the complication of S jögren's syndrome, severe facial skin sclerosis and atrophy of the thyroid gland were significantly prevalent in SS c patients with AITD . SS c patients with such clinical features may be at high risk of AITD and require regular follow up of thyroid function including ultrasonography and the examination of serum hormone levels to start an early treatment.