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Antifungal effect of TONS 504‐photodynamic therapy on M alassezia furfur
Author(s) -
Takahashi Hidetoshi,
Nakajima Susumu,
Sakata Isao,
Iizuka Hajime
Publication year - 2014
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12615
Subject(s) - photodynamic therapy , acne , antifungal , photosensitizer , therapeutic effect , dermatology , medicine , chemistry , pharmacology , photochemistry , organic chemistry
Numerous reports indicate therapeutic efficacy of photodynamic therapy ( PDT ) against skin tumors, acne and for skin rejuvenation. However, few reports exist regarding its efficacy for fungal skin diseases. In order to determine the antifungal effect, PDT was applied on Malassezia furfur . M. furfur was cultured in the presence of a novel cationic photosensitizer, TONS 504, and was irradiated with a 670‐nm diode laser. TONS 504‐ PDT showed a significant antifungal effect against M. furfur . The effect was irradiation dose‐ and TONS 504 concentration‐dependent and the maximal effect was observed at 100 J/cm 2 and 1 μg/mL, respectively. In conclusion, TONS 504‐ PDT showed antifungal effect against M. furfur in vitro , and may be a new therapeutic modality for M. furfur ‐related skin disorders.