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Scleroderma renal crisis following pericardial effusion in a Japanese female
Author(s) -
Shu En,
Kanoh Hiroyuki,
Seishima Mariko
Publication year - 2014
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12574
Subject(s) - medicine , pericardial effusion , pericarditis , autoantibody , scleroderma (fungus) , progressive systemic sclerosis , cardiology , thickening , effusion , gastroenterology , pathology , surgery , immunology , antibody , disease , inoculation , chemistry , polymer science
Scleroderma renal crisis ( SRC ) occurs in 4–5% of Japanese patients with systemic sclerosis ( SS c) and is one of the most severe complications, along with interstitial pneumonia and pulmonary hypertension, which lead to a poor outcome. The factors predicting SRC include diffuse progressive skin thickening, a duration of SS c of 4 years or less, having autoantibodies against RNA polymerase III , systemic corticosteroid ( CS ) administration and recent cardiac events, including pericarditis. We herein report a female case of SRC preceded by pericardial effusion during the treatment with CS for rapidly progressive skin thickening. She had none of the known autoantibodies and was successfully treated with an angiotensin II receptor blocker.