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Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis
Author(s) -
Takahashi Takehiro,
Asano Yoshihide,
Sunaga Ryo,
Ichimura Yohei,
Taniguchi Takashi,
Yamamoto Mizuho,
Tamaki Zenshiro,
Takekoshi Tomonori,
Mitsui Hiroshi,
Sugaya Makoto,
Ohse Takamoto,
Sato Shinichi
Publication year - 2014
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12495
Subject(s) - medicine , scleroderma (fungus) , hemodialysis , cyclophosphamide , interstitial lung disease , lung , chemotherapy , pathology , inoculation
Interstitial lung disease and scleroderma renal crisis are major complications of systemic sclerosis, which occasionally coexist in patients with the diffuse cutaneous subtype. We herein report a case of diffuse cutaneous systemic sclerosis under hemodialysis due to a previous history of scleroderma renal crisis, whose interstitial lung disease was effectively and safely treated with a half dose of i.v. cyclophosphamide pulse. The dose of cyclophosphamide and the timing of hemodialysis leading to efficacy and low toxicity are discussed.