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Case of primary cutaneous peripheral T‐cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells
Author(s) -
Takaki Machiko,
Inozume Takashi,
Matsuzawa Takamitsu,
Ando Noriko,
Yamaguchi Miyuki,
Harada Kazutoshi,
Kawamura Tatsuyoshi,
Shibagaki Naotaka,
Shimada Shinji
Publication year - 2014
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12493
Subject(s) - pathology , immunohistochemistry , dermis , flow cytometry , lymphoma , infiltration (hvac) , t cell , t cell lymphoma , peripheral , medicine , cell , biology , immunology , immune system , genetics , physics , thermodynamics
We report a case of an 88‐year‐old woman with a decalvant, erythematous, ulcerated tumor extending from the right temporal to occipital region. Histopathological analysis revealed a dense infiltration of medium‐to‐large‐sized atypical cells throughout the entire dermis. The result of immunohistochemical analysis showed that the infiltrating T cells expressed programmed death‐1 ( PD ‐1), B cl‐6 and CXCL 13. Flow cytometry analysis showed that CD 4 + PD ‐1 hi T cells also expressed CD 10, inducible T‐cell co‐stimulator and CXCR 5. On the basis of the clinical appearance and the histopathological findings, we diagnosed the patient with primary cutaneous peripheral T‐cell lymphoma, not otherwise specified. Recently, the concept of primary cutaneous follicular helper T ( TFH )‐cell lymphoma was proposed, and in this case, tumor cells clearly expressed TFH ‐cell markers. Therefore, we considered this case to be a variant of the entity. Although this entity is still provisional, this case supports the new concept.