Premium
Comorbidities and health‐related quality of life in Spanish patients with moderate to severe psoriasis: A cross‐sectional study (Arizona study)
Author(s) -
SanchezCarazo Jose Luis,
LópezEstebaranz Jose Luis,
Guisado Cristina
Publication year - 2014
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12465
Subject(s) - medicine , psoriasis , psoriatic arthritis , anxiety , depression (economics) , quality of life (healthcare) , epidemiology , observational study , fibromyalgia , cross sectional study , comorbidity , population , diabetes mellitus , obesity , metabolic syndrome , physical therapy , dermatology life quality index , patient health questionnaire , disease , dermatology , psychiatry , depressive symptoms , pathology , environmental health , nursing , economics , macroeconomics , endocrinology
Psoriasis is a common, chronic inflammatory immunologically mediated disease of the skin, showing a high prevalence of associated comorbidities, and strongly affecting patients' health‐related quality of life ( HR‐QOL ), with profound impact on the psychological aspect. We aimed to establish the correlation between HR‐QOL and the associated comorbidities in patients with moderate to severe psoriasis in S pain. A cross‐sectional, observational, epidemiological study was conducted at 68 dermatology‐based centers across S pain. From O ctober 2010 to J une 2011, all adult patients diagnosed with moderate to severe psoriasis at least 6 months prior to the study visit and receiving or not receiving treatment for psoriasis were eligible for inclusion. A total of 1022 patients were included. The study population showed mean 36‐item short‐form ( SF‐36 ) physical and mental health scores and D ermatological L ife Q uality I ndex ( DLQI ) of 49.7, 46.2 and 5.3, respectively. The multiple linear regression models showed that patients with moderate to severe psoriasis and a diagnosis of psoriatic arthritis ( P s A ), hypertension, diabetes mellitus, sleep disturbances or obesity were found to have lower SF‐36 health physical scores. Female patients with depression or anxiety disorders had lower SF‐36 health mental scores. Patients diagnosed with moderate to severe psoriatic disease and associated anxiety disorder had greater DLQI scores. Moderate to severe psoriasis has a significant burden on the HR‐QOL of patients. Regardless of sex, patients with several comorbidities such as P s A , hypertension or obesity were found to have worse scores in the physical component of the QOL questionnaire, whilst women were more affected in the mental health component than men.