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Ocular involvement in pemphigus vulgaris
Author(s) -
Akhyani Maryam,
KeshtkarJafari Alireza,
ChamsDavatchi Cheyda,
Lajevardi Vahide,
Beigi Sara,
Aghazadeh Nessa,
Rayati Damavandi Maede,
Arami Shabnam
Publication year - 2014
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12447
Subject(s) - medicine , pemphigus vulgaris , dermatology , palpebral fissure , conjunctiva , epidemiology , population , eye disease , irritation , allergic conjunctivitis , ophthalmology , pathology , immunology , allergy , environmental health
Pemphigus vulgaris ( PV ) is an autoimmune disorder affecting the skin and mucous membranes. Ocular involvement in PV has been reported but its prevalence and clinical characteristics are not well defined. This prospective cross‐sectional study of 103 PV patients was designed to determine the prevalence, clinical types and epidemiological trends of ocular involvement in a population of I ranian patients with PV . Ocular involvement was present in 17 (16.5%) patients. Conjunctivitis was the most prevalent type of ocular involvement (9/17, 52.9%), followed by erosion of the palpebral conjunctiva (7/17, 41.2%). Erosion of the bulbar conjunctiva was noted in only one patient (5.9%). The most commonly reported symptoms were eye irritation (76.5%) and redness (76.5%). No significant relation was found between ocular involvement and disease activity (partial remission or relapse). Mucoid discharge was significantly more common in patients with conjunctival erosions as compared to patients with conjunctivitis ( P = 0.038). We conclude that ocular involvement is not rare in PV ; 16.5% of PV patients develop ocular disease independent of the disease activity and extension. Conjunctivitis is the most common type of involvement, however, palpebral conjunctival erosion is more frequent than previously realized.