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Influence of abiotic factors on the antimicrobial activity of chitosan
Author(s) -
Tavaria Freni K.,
Costa Eduardo M.,
Gens Eduardo J.,
Malcata Francisco Xavier,
Pintado Manuela E.
Publication year - 2013
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12315
Subject(s) - antimicrobial , chitosan , staphylococcus epidermidis , chemistry , atopic dermatitis , abiotic component , food science , microbiology and biotechnology , medicine , staphylococcus aureus , biochemistry , bacteria , biology , organic chemistry , immunology , paleontology , genetics
In an effort to bypass the adverse secondary effects attributed to the traditional therapeutic approaches used to treat skin disorders (such as atopic dermatitis), alternative antimicrobials have recently been suggested. One such antimicrobial is chitosan, owing to the already proved biological properties associated with its use. However, the influence of abiotic factors on such activities warrants evaluation. This research effort assessed the antimicrobial activity of chitosan upon skin microorganisms ( S taphylococcus aureus , S taphylococcus epidermidis and E scherichia coli ) in vitro when subject to a combination of different abiotic factors such as p H , ionic strength, organic acids and free fatty acids. Free fatty acids, ionic strength and p H significantly affected chitosan's capability of reducing the viable numbers of S . aureus . This antimicrobial action was potentiated in the presence of palmitic acid and a lower ionic strength (0.2% N a C l), while a higher ionic strength (0.4% N a C l) favored chitosan's action upon the reduction of viable numbers of S . epidermidis and E . coli . Although further studies are needed, these preliminary results advocate that chitosan can in the future be potentially considered as an antimicrobial of choice when handling symptoms associated with atopic dermatitis.