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Narrowband ultraviolet B irradiation increases the serum level of vitamin D 3 in patients with neurofibromatosis 1
Author(s) -
Nakayama Juichiro,
Imafuku Shinichi,
Mori Tatsuki,
Sato Chiemi
Publication year - 2013
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12256
Subject(s) - ultraviolet , ultraviolet irradiation , narrowband , vitamin , ultraviolet radiation , irradiation , chemistry , medicine , endocrinology , materials science , computer science , physics , optoelectronics , telecommunications , radiochemistry , nuclear physics
The serum vitamin D 3 levels in patients with neurofibromatosis 1 has been reported to be significantly lower than that in control subjects, and the level of vitamin D 3 reversely correlates with the severity of neurofibroma formation. We found that narrowband ultraviolet B ( NB‐UVB ) irradiation increased the serum level of 1,25( OH ) 2 vitamin D 3 in patients with neurofibromatosis 1. The difference in the 1,25( OH ) 2 vitamin D 3 levels between patients who had received irradiation for more than 18 months and those who had no irradiation was highly significant. Time‐course analyses of the serum vitamin D 3 levels in the patients who were enrolled after informed consent revealed that the levels became higher significantly after 6 months of irradiation. It is suggested that NB‐UVB irradiation is effective for increasing the serum level of vitamin D 3 in patients with neurofibromatosis 1, which may be of benefit for skin symptoms such as pigmented macules or neurofibromas.