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Solitary angiokeratoma on palms and soles: A clinicopathological analysis of 21 cases
Author(s) -
Wang Lei,
Gao Tianwen,
Wang Gang
Publication year - 2013
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12192
Subject(s) - angiokeratoma , hyperkeratosis , dermis , pathology , papillary dermis , palm , medicine , lumen (anatomy) , immunohistochemistry , anatomy , dermatology , surgery , physics , quantum mechanics
Angiokeratoma includes a group of unrelated diseases characterized by hyperkeratosis and dilation of vessels in the superficial dermis. In this study, 21 cases of solitary lesions located on palms and soles and histopathologically diagnosed as angiokeratoma were analyzed retrospectively. All lesions presented as red to violet macules or plaques. Histopathologically, all of them showed hyperkeratosis and vascular dilation in the papillary to deep dermis. The elongated vessels were of different sizes and shape, lined by a single layer of endothelial cells. In 13 lesions, the endothelial cells protruded into the lumen, forming a hobnail appearance. Immunohistochemical study showed the endothelial cells were positive for CD 31 and CD 34, negative for D2‐40, and focally positive for W ilms tumor 1 ( WT ‐1) in most cases. Our cases represented a rare type of angiokeratoma located on the palms and soles, in which the focal positivity of WT ‐1 was different from previously reported vascular proliferations.