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Adiponectin levels in patients with psoriasis: A meta‐analysis
Author(s) -
Zhu KunJu,
Shi Ge,
Zhang Chi,
Li Ming,
Zhu ChengYao,
Fan YiMing
Publication year - 2013
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12121
Subject(s) - adiponectin , psoriasis , meta analysis , medicine , dermatology , obesity , insulin resistance
Conflicting results regarding adiponectin levels in patients with psoriasis have been reported. We carried out a meta‐analysis on studies which compared adiponectin levels of psoriatic patients with controls. A published work search was performed through P ub M ed ( MEDLINE ), EMBASE and the C ochrane L ibrary for articles published in E nglish. Pooled standardized mean difference ( SMD ) and 95% confidence intervals (95% CI ) were calculated by using random effects and fixed effect models. Heterogeneity between studies was assessed using the C ochran's Q and I 2 statistics. A total of nine studies were enrolled (389 cases and 360 controls) for adiponectin, and three studies were included (132 cases and 132 controls) for high‐molecular weight ( HMW ) adiponectin. Adiponectin and HMW adiponectin levels were not significantly different in patients with psoriasis compared with controls ( SMD , −0.151 [95% CI , −0.616 to 0.315]; P = 0.526 for adiponectin; SMD , 0.999 [95% CI , −2.626 to 4.624]; P = 0.589 for HMW adiponectin). The associations were borderline significantly different in the stratum of those with a mean age of less than 40 years ( SMD , −0.516 [95% CI : −1.032 to 0]; P = 0.050). Sensitivity analyses were not substantially altered in the direction of effect when any one study was excluded. No publication bias was detected. The level of adiponectin and HMW adiponectin may not be associated with psoriasis. The relationship between psoriasis and adipokines needs more in‐depth studies with larger sample sizes.