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Pustular‐type drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to carbamazepine with systemic muscle involvement
Author(s) -
Matsuda Haruna,
Saito Kanami,
Takayanagi Yoshikazu,
Okazaki Toshio,
Kashima Kenji,
Ishikawa Kazushi,
Kai Yoshitaka,
Takeo Naoko,
Hatano Yutaka,
Okamoto Osamu,
Fujiwara Sakuhei
Publication year - 2013
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12028
Subject(s) - carbamazepine , medicine , acute generalized exanthematous pustulosis , pustulosis , drug , dermatology , eosinophilia , idiosyncrasy , hypersensitivity reaction , drug eruption , immunology , pharmacology , epilepsy , arthritis , finance , psychiatry , economics , synovitis
Drug‐induced hypersensitivity syndrome ( DIHS )/drug reaction with eosinophilia and systemic symptoms ( DRESS ) is a severe reaction usually associated with maculopapular eruptions and systemic involvement. Here we report the first case, to our knowledge, of DIHS / DRESS due to carbamazepine with acute generalized pustular bacterid‐like ( AGPB ‐like) eruptions and skeletal muscle involvement. Reviewing our case and the published work, we discuss pustular‐type DIHS / DRESS which, in most cases, involves acute generalized exanthematous pustulosis ( AGEP )‐like skin eruptions in response to carbamazepine. Pustular eruptions may appear in relatively few cases of DIHS / DRESS , in particular, when the causative drug is carbamazepine and, even in cases of intractable pustular bacterid‐like eruptions, a reaction to a drug should be suspected. Skeletal muscle involvement may be associated with DIHS / DRESS as one of its systemic manifestations.