Open AccessFolate degradation due to ultraviolet radiation: possible implications for human health and nutrition
Author(s) -
Borradale David C,
Kimlin Michael G
Publication year - 2012
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/j.1753-4887.2012.00485.x
Subject(s) - human health , folic acid , megaloblastic anemia , medicine , ultraviolet radiation , environmental health , anemia , physiology , chemistry , radiochemistry
Folate is essential for human health in the prevention of megaloblastic anemia and neural tube birth defects and plays important roles in cardiovascular disease and cancer. Therefore, research into environmental factors that may impact folate status, such as solar ultraviolet (UV) radiation, is of great health significance. In vitro studies have shown that UV radiation can degrade folate and folic acid in human blood and this has been confirmed in several human studies. Despite these findings, there is a dearth of epidemiological research into investigating the relationship between folate status and the links to solar UV exposure.