Premium
The L6 membrane proteins—A new four‐transmembrane superfamily
Author(s) -
Wright Mark D.,
Rudy George B.,
Ni Jian
Publication year - 2000
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.9.8.1594
Subject(s) - superfamily , transmembrane protein , tetraspanin , transmembrane domain , membrane protein , biology , sequence (biology) , computational biology , peptide sequence , protein superfamily , sequence alignment , microbiology and biotechnology , genetics , membrane , cell , gene , receptor
L6, IL‐TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL‐TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.