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Decoys ‘R’ Us: A database of incorrect conformations to improve protein structure prediction
Author(s) -
Samudrala Ram,
Levitt Michael
Publication year - 2000
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.9.7.1399
Subject(s) - computer science , set (abstract data type) , protein structure prediction , function (biology) , resource (disambiguation) , protein structure , database , protein structure database , data mining , chemistry , biology , computer network , biochemistry , evolutionary biology , programming language , sequence database , gene
The development of an energy or scoring function for protein structure prediction is greatly enhanced by testing the func–tion on a set of computer–generated conformations (decoys) to determine whether it can readily distinguish native–like conforma–tions from nonnative ones. We have created “Decoys “R” Us,” a database containing many such sets of conformations, to provide a resource that allows scoring functions to be improved.