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The PA domain: A protease‐associated domain
Author(s) -
Mahon Piers,
Bateman Alex
Publication year - 2000
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.9.10.1930
Subject(s) - egf like domain , hamp domain , domain (mathematical analysis) , ring finger domain , protein domain , transferrin receptor , zinc finger , biology , protease , microbiology and biotechnology , receptor , transferrin , chemistry , biochemistry , gene , enzyme , mathematical analysis , mathematics , transcription factor
Abstract We have identified a similarity between the apical domain of the human transferrin receptor and several other protein families. This domain is found associated with two different families of peptidases. Therefore, we term it the PA domain for protease‐associated domain. The PA domain is found inserted within a loop of the peptidase domain of family M8/M33 zinc peptidases. The PA domain is also found in a vacuolar sorting receptor and a ring finger protein of unknown function that may be a cell surface receptor. The PA domain may mediate substrate determination of peptidases or form protein‐protein interactions.