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Quantitative evaluation of the lengths of homobifunctional protein cross‐linking reagents used as molecular rulers
Author(s) -
Green Nora S.,
Reisler Emil,
Houk K.N.
Publication year - 2001
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.51201
Subject(s) - characterization (materials science) , molecular dynamics , molecule , statistical physics , chemistry , biological system , chemical physics , biophysics , nanotechnology , materials science , computational chemistry , physics , biology , organic chemistry
Homobifunctional chemical cross‐linking reagents are important tools for functional and structural characterization of proteins. Accurate measures of the lengths of these molecules currently are not available, despite their widespread use. Stochastic dynamics calculations now provide quantitative measures of the lengths, and length dispersions, of 32 widely used molecular rulers. Significant differences from published data have been found.