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Determinants of quaternary association in legume lectins
Author(s) -
Brinda K.V.,
Mitra Nivedita,
Surolia Avadhesha,
Vishveshwara Saraswathi
Publication year - 2004
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.04651004
Subject(s) - protein quaternary structure , quaternary , sequence (biology) , biology , peptide sequence , sequence motif , computational biology , sequence homology , protein tertiary structure , structural motif , evolutionary biology , genetics , paleontology , biochemistry , protein subunit , gene
It is well known that the sequence of amino acids in proteins code for its tertiary structure. It is also known that there exists a relationship between sequence and the quaternary structure of proteins. The question addressed here is whether the nature of quaternary association can be predicted from the sequence, similar to the three‐dimensional structure prediction from the sequence. The class of proteins called legume lectins is an interesting model system to investigate this problem, because they have very high sequence and tertiary structure homology, with diverse forms of quaternary association. Hence, we have used legume lectins as a probe in this paper to (1) gain novel insights about the relationship between sequence and quaternary structure; (2) identify the sequence motifs that are characteristic of a given type of quaternary association; and (3) predict the quaternary association from the sequence motif.