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Kinetic barriers and the role of topology in protein and RNA folding
Author(s) -
Sosnick Tobin R.
Publication year - 2008
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.036319.108
Subject(s) - folding (dsp implementation) , protein folding , topology (electrical circuits) , rna , biophysics , downhill folding , chemistry , computational biology , phi value analysis , chemical physics , biology , microbiology and biotechnology , biochemistry , gene , mathematics , engineering , combinatorics , electrical engineering
This review compares the folding behavior of proteins and RNAs. Topics covered include the role of topology in the determination of folding rates, major folding events including collapse, properties of denatured states, pathway heterogeneity, and the influence of the mode of initiation on the folding pathway.