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Allostery and cooperativity revisited
Author(s) -
Cui Qiang,
Karplus Martin
Publication year - 2008
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.03259908
Subject(s) - cooperativity , allosteric regulation , presentation (obstetrics) , perspective (graphical) , statistical physics , computer science , positive economics , chemistry , physics , economics , artificial intelligence , medicine , biochemistry , radiology , enzyme
Abstract Although phenomenlogical models that account for cooperativity in allosteric systems date back to the early and mid‐60's (e.g., the KNF and MWC models), there is resurgent interest in the topic due to the recent experimental and computational studies that attempted to reveal, at an atomistic level, how allostery actually works. In this review, using systems for which atomistic simulations have been carried out in our groups as examples, we describe the current understanding of allostery, how the mechanisms go beyond the classical MWC/Pauling‐KNF descriptions, and point out that the “new view” of allostery, emphasizing “population shifts,” is, in fact, an “old view.” The presentation offers not only an up‐to‐date description of allostery from a theoretical/computational perspective, but also helps to resolve several outstanding issues concerning allostery.