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H‐bonding mediates polarization of peptide groups in folded proteins
Author(s) -
Juranić Nenad,
Macura Slobodan,
Prendergast Franklyn G.
Publication year - 2003
Publication title -
protein science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.353
H-Index - 175
eISSN - 1469-896X
pISSN - 0961-8368
DOI - 10.1110/ps.03127103
Subject(s) - peptide , hydrogen bond , chemistry , protein secondary structure , protein structure , crystallography , polarization (electrochemistry) , protein tertiary structure , biophysics , biochemistry , molecule , biology , organic chemistry
The carbon‐nitrogen J‐couplings in the hydrogen bonding chains of proteins show that H‐bonding mediates peptide‐group polarization, which results in the general reduction of peptide‐group polarity of folded proteins in solution. The net effect is to make large regions of protein secondary structure, especially β‐sheets, intrinsically more hydrophobic, contributing thereby to overall stability of the tertiary structure.