Open AccessNeural Probes with Integrated Temperature Sensors for Monitoring Retina and Brain Implantation and Stimulation
Author(s) -
Jiaqi Wang,
Hui Xie,
Tsing Chung,
Leanne Lai Hang Chan,
Stella W. Pang
Publication year - 2017
Publication title -
ieee transactions on neural systems and rehabilitation engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 140
eISSN - 1558-0210
pISSN - 1534-4320
DOI - 10.1109/tnsre.2016.2634584
Subject(s) - bioengineering , computing and processing , robotics and control systems , signal processing and analysis , communication, networking and broadcast technologies
Gold (Au) resistive temperature sensors were integrated on flexible polyimide-based neural probes to monitor temperature changes during neural probe implantation and stimulation. Temperature changes were measured as neural probes were implanted to infer the positions of the neural probes, and as the retina or the deep brain region was stimulated electrically. The temperature sensor consisted of a serpentine Au resistor and surrounded by four Au electrodes with 200 and 400 μm diameter (dia.). The Au temperature sensors had temperature coefficient of 0.32%, and they were biocompatible and small in size. In vivo measurements of temperature changes during implantation and stimulation were carried out in the retina and deep brain region in rats. The desired implantation position was reached when temperature measured by the sensor increased to the calibrated level and became stable. There was no temperature increase when low level stimulation current of 8 and 13 μA each for the two 200and 400-μm-dia. electrodes, respectively, were applied. When higher level stimulation current of 100 and 200 μA each were applied to the two 200and 400μm-dia. electrodes, respectively, maximum temperature increases of 1.2 °C in retina and 1 °C in deep brain region were found.