z-logo
open-access-imgOpen Access
Spindle-AI: Sleep Spindle Number and Duration Estimation in Infant EEG
Author(s) -
Lan Wei,
Soraia Ventura,
Sean Mathieson,
Geraldine Boylan,
Madeleine Lowery,
Catherine Mooney
Publication year - 2021
Publication title -
ieee transactions on biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.148
H-Index - 200
eISSN - 1558-2531
pISSN - 0018-9294
DOI - 10.1109/tbme.2021.3097815
Subject(s) - bioengineering , computing and processing , components, circuits, devices and systems , communication, networking and broadcast technologies
Objective: Sleep spindle features show developmental changes during infancy and have the potential to provide an early biomarker for abnormal brain maturation. Manual identification of sleep spindles in the electroencephalogram (EEG) is time-consuming and typically requires highly-trained experts. Automated detection of sleep spindles would greatly facilitate this analysis. Research on the automatic detection of sleep spindles in infant EEG has been limited to-date. Methods: We present a random forest-based sleep spindle detection method (Spindle-AI) to estimate the number and duration of sleep spindles in EEG collected from 141 ex-term born infants, recorded at 4 months of age. The signal on channel F4-C4 was split into a training set (81 ex-term) and a validation set (30 ex-term). An additional 30 ex-term infant EEGs (channel F4-C4 and channel F3-C3) were used as an independent test set. Fourteen features were selected for input into a random forest algorithm to estimate the number and duration of spindles and the results were compared against sleep spindles annotated by an experienced clinical physiologist. Results: The prediction of the number of sleep spindles in the independent test set demonstrated 93.3% to 93.9% sensitivity, 90.7% to 91.5% specificity, and 89.2% to 90.1% precision. The duration estimation of sleep spindle events in the independent test set showed a percent error of 5.7% to 7.4%. Conclusion and Significance: Spindle-AI has been implemented as a web server that has the potential to assist clinicians in the fast and accurate monitoring of sleep spindles in infant EEGs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here