Open AccessNeuroBus - Architecture for an Ultra-Flexible Neural Interface
Author(s) -
Markus Sporer,
Ioana-Georgiana Vasilas,
Ahmed Adzemovic,
Nicolas Graber,
Stefan Reich,
Calogero Gueli,
Max Eickenscheidt,
Ilka Diester,
Thomas Stieglitz,
Maurits Ortmanns
Publication year - 2024
Publication title -
ieee transactions on biomedical circuits and systems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.02
H-Index - 73
eISSN - 1940-9990
pISSN - 1932-4545
DOI - 10.1109/tbcas.2024.3354785
Subject(s) - bioengineering , components, circuits, devices and systems
This article presents the system architecture for an implant concept called NeuroBus . Tiny distributed direct digitizing neural recorder ASICs on an ultra-flexible polyimide substrate are connected in a bus-like structure, allowing short connections between electrode and recording front-end with low wiring effort and high customizability. The small size (344 $\,\mu$ m × 294 $\mu$ m) of the ASICs and the ultraflexible substrate allow a low bending stiffness, enabling the implant to adapt to the curvature of the brain and achieving high structural biocompatibility. We introduce the architecture, the integrated building blocks, and the post-CMOS processes required to realize a NeuroBus , and we characterize the prototyped direct digitizing neural recorder front-end as well as polyimide-based ECoG brain interface. A rodent animal model is further used to validate the joint capability of the recording front-end and thin-film electrode array.