Open AccessNon-Invasive Neuromodulation Using Time-Varying Caloric Vestibular Stimulation
Author(s) -
Robert D. Black,
Lesco L. Rogers,
Kristen K. Ade,
Heather A. Nicoletto,
Heather D. Adkins,
Daniel T. Laskowitz
Publication year - 2016
Publication title -
ieee journal of translational engineering in health and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.653
H-Index - 24
ISSN - 2168-2372
DOI - 10.1109/jtehm.2016.2615899
Subject(s) - bioengineering , communication, networking and broadcast technologies , components, circuits, devices and systems , computing and processing , signal processing and analysis , robotics and control systems , general topics for engineers
Caloric vestibular stimulation (CVS) to elicit the vestibulo-ocular reflex has long been used in clinical settings to aid in the diagnosis of balance disorders and to confirm the absence of brainstem function. While a number of studies have hinted at the potential therapeutic applications of CVS, the limitations of existing devices have frustrated that potential. Current CVS irrigators use water or air during short-duration applications; however, this approach is not tenable for longer duration therapeutic protocols or home use. Here, we describe a solid-state CVS device we developed in order to address these limitations. This device delivers tightly controlled time-varying thermal waveforms, which can be programmed through an external control unit. It contains several safety features, which limit patients to the prescribed waveform and prevent the potential for temperature extremes. In this paper, we provide evidence that CVS treatment with time-varying, but not constant temperature waveforms, elicits changes in cerebral blood flow physiology consistent with the neuromodulation of brainstem centers, and we present results from a small pilot study, which demonstrate that the CVS can safely and feasibly be used longitudinally in the home setting to treat episodic migraine. Together, these results indicate that this solid-state CVS device may be a viable tool for non-invasive neuromodulation.