Open AccessMultispectral Endoscopy With Light Gating for Early Cancer Detection
Author(s) -
Le Qiu,
Lei Zhang,
Vladimir Turzhitsky,
Umar Khan,
Yu. P. Zakharov,
Mandeep S. Sawhney,
Tyler M. Berzin,
Jeffrey D. Goldsmith,
Kanchan Kantekure,
Edward Vitkin,
Irving Itzkan,
Lev T. Perelman
Publication year - 2019
Publication title -
ieee journal of selected topics in quantum electronics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.131
H-Index - 159
eISSN - 1558-4542
pISSN - 1077-260X
DOI - 10.1109/jstqe.2018.2854608
Subject(s) - light scattering , gating , optics , dysplasia , scattering , pathology , medicine , physics , physiology
This paper reports the application of endoscopic light scattering spectroscopy (LSS) with light gating to detect malignancies in the biliary and pancreatic ducts, and also reviews the application of endoscopic LSS for differentiating cystic neoplasms in the pancreas and detecting invisible dysplasia in Barrett's esophagus. Information about tissue structure within the superficial epithelium where malignancy starts is present within the spectra of reflected light. Fortunately, this component of the reflected light is not yet randomized. However multiple scattering randomizes the signal from the underlying connective tissue which obscures the desired signal. In order to extract diagnostic information from the reflected signal the multiple scattering component related to connective tissue scattering and absorption must be removed. This is accomplished using described here spatial or polarization gating implemented with endoscopically compatible fiber optic probes.