Open AccessA Label-Free Optical Biosensor Built on a Low-Cost Polymer Platform
Author(s) -
Linghua Wang,
Jun Ren,
Xiuyou Han,
Tom Claes,
Xigao Jian,
Peter Bienstman,
Roel Baets,
Mingshan Zhao,
Geert Morthier
Publication year - 2012
Publication title -
ieee photonics journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 73
eISSN - 1943-0655
pISSN - 1943-0647
DOI - 10.1109/jphot.2012.2200671
Subject(s) - engineered materials, dielectrics and plasmas , photonics and electrooptics
Planar integrated optical biosensors are becoming more and more important as they facilitate label-free and real-time monitoring with high sensitivity. In this paper, the systematic work on the development of this kind of optical biosensor built on a novel polymer platform named PSQ-Ls will be presented. The material itself is of very low cost, and the optical devices with high performances are fabricated through a simple UV-based soft imprint lithography technique. Especially for ring resonator, Q value as high as 5 × 104 and 2.7 × 104 are achieved in air and water condition. These optical chips are functionalized efficiently with protein A molecules through physical immobilization, after careful investigation of the physicochemical and chemical properties of their surface. Both bulk sensing and surface sensing are performed. The proposed optical biosensor exhibits good response not only to its surrounding environment's change but also to the small amount of targeted molecules appearing in the buffered solution, which is human-IgG in our study.