First Positronium Imaging Using  44 Sc With the J-PET Scanner: a Case Study on the NEMA-Image Quality Phantom | Zendy

Manish Das | Zendy; Sushil Sharma | Zendy; Ermias Yitayew Beyene | Zendy; Aleksander Bilewicz | Zendy; Jaroslaw Choinski | Zendy; Neha Chug | Zendy; Catalina Curceanu | Zendy; Eryk Czerwinski | Zendy; Kavya Valsan Eliyan | Zendy; Jakub Hajduga | Zendy; Sharareh Jalali | Zendy; Krzysztof Kacprzak | Zendy; Tevfik Kaplanoglu | Zendy; Lukasz Kaplon | Zendy; Kamila Kasperska | Zendy; Aleksander Khreptak | Zendy; Grzegorz Korcyl | Zendy; Tomasz Kozik | Zendy; Karol Kubat | Zendy; Deepak Kumar | Zendy; Anoop Kunimmal Venadan | Zendy; Edward Lisowski | Zendy; Filip Lisowski | Zendy; Justyna Medrala-Sowa | Zendy; Simbarashe Moyo | Zendy; Wiktor Mryka | Zendy; Szymon Niedzwiecki | Zendy; Piyush Pandey | Zendy; Szymon Parzych | Zendy; Alessio Porcelli | Zendy; Bartlomiej Rachwal | Zendy; Elena Perez del Rio | Zendy; Martin Radler | Zendy; Axel Rominger | Zendy; Kuangyu Shi | Zendy; Magdalena Skurzok | Zendy; Anna Stolarz | Zendy; Tomasz Szumlak | Zendy; Pooja Tanty | Zendy; Keyvan Tayefi Ardebili | Zendy; Satyam Tiwari | Zendy; Rafal Walczak | Zendy; Ewa L. Stepien | Zendy; Pawel Moskal | Zendy

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First Positronium Imaging Using 44 Sc With the J-PET Scanner: a Case Study on the NEMA-Image Quality Phantom

Author(s) -

Manish Das,

Sushil Sharma,

Ermias Yitayew Beyene,

Aleksander Bilewicz,

Jaroslaw Choinski,

Neha Chug,

Catalina Curceanu,

Eryk Czerwinski,

Kavya Valsan Eliyan,

Jakub Hajduga,

Sharareh Jalali,

Krzysztof Kacprzak,

Tevfik Kaplanoglu,

Lukasz Kaplon,

Kamila Kasperska,

Aleksander Khreptak,

Grzegorz Korcyl,

Tomasz Kozik,

Karol Kubat,

Deepak Kumar,

Anoop Kunimmal Venadan,

Edward Lisowski,

Filip Lisowski,

Justyna Medrala-Sowa,

Simbarashe Moyo,

Wiktor Mryka,

Szymon Niedzwiecki,

Piyush Pandey,

Szymon Parzych,

Alessio Porcelli,

Bartlomiej Rachwal,

Elena Perez del Rio,

Martin Radler,

Axel Rominger,

Kuangyu Shi,

Magdalena Skurzok,

Anna Stolarz,

Tomasz Szumlak,

Pooja Tanty,

Keyvan Tayefi Ardebili,

Satyam Tiwari,

Rafal Walczak,

Ewa L. Stepien,

Pawel Moskal

Publication year - 2025

Publication title -

ieee transactions on radiation and plasma medical sciences

Language(s) - English

Resource type - Magazines

eISSN - 2469-7303

pISSN - 2469-7311

DOI - 10.1109/trpms.2025.3621554

Subject(s) - nuclear engineering , engineered materials, dielectrics and plasmas , bioengineering , computing and processing , fields, waves and electromagnetics

Positronium Lifetime Imaging (PLI), an emerging extension of conventional positron emission tomography (PET) imaging, offers a novel window for probing the submolecular properties of biological tissues by imaging the mean lifetime of the positronium atom. Currently, the method is under rapid development in terms of reconstruction and detection systems. Recently, the first in vivo PLI of the human brain was performed using the J-PET scanner utilizing the 68Ga isotope. However, this isotope has limitations due to its comparatively low prompt gamma yields, which is crucial for positronium lifetime measurement. Among alternative radionuclides, 44Sc stands out as a promising isotope for PLI, characterized by a clinically suitable half-life (4.04 hours) emitting 1157 keV prompt gamma in 100% cases after the emission of the positron. This study reports the first experimental demonstration of PLI with 44Sc, carried out on a NEMA-Image Quality (IQ) phantom using the Modular J-PET tomograph–the first plastic scintillators-based PET scanner.

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