Open Access(3β,5α,25R)-12-(Hydroxyimino)spirostan-3-yl acetate
Author(s) -
Alan Carrasco-Carballo,
Gabriel GuerreroLuna,
Mathieu Linares,
Sylvain Bernès
Publication year - 2017
Publication title -
iucrdata
Language(s) - English
Resource type - Journals
ISSN - 2414-3146
DOI - 10.1107/s2414314617004916
Subject(s) - chemistry , oxime , ring (chemistry) , hydrogen bond , stereochemistry , crystal structure , steroid , intermolecular force , group (periodic table) , functional group , derivative (finance) , crystallography , medicinal chemistry , molecule , organic chemistry , biochemistry , hormone , financial economics , economics , polymer
The title steroid, C29H45NO5, obtained by condensation of hecogenin acetate [systematic name: (3β,5α,25R)-12-oxospirostan-3-yl acetate] with NH2OH, has the oxime group substituting the C-12 site on the C ring of the steroid nucleus. The introduction of this functional group allows the formation of chain motifs, using the oxime OH group as a donor and the O atom of the E ring as an acceptor. The C(8) chains formed by this intermolecular hydrogen bond are oriented parallel to the short cell axis a. The structural features of this compound are very close to those of C29H43NO5, the derivative with a C14=C15 double bond in the D ring, which crystallizes in the same space group and with similar unit-cell parameters