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CM01: a facility for cryo‐electron microscopy at the European Synchrotron
Author(s) -
Kandiah Eaazhisai,
Giraud Thierry,
de Maria Antolinos Alejandro,
Dobias Fabien,
Effantin Gregory,
Flot David,
Hons Michael,
Schoehn Guy,
Susini Jean,
Svensson Olof,
Leonard Gordon A.,
Mueller-Dieckmann Christoph
Publication year - 2019
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.374
H-Index - 138
ISSN - 2059-7983
DOI - 10.1107/s2059798319006880
Subject(s) - beamline , synchrotron radiation , synchrotron , electron microscope , cryo electron microscopy , microscopy , nanotechnology , physics , optics , materials science , nuclear magnetic resonance , beam (structure)
Recent improvements in direct electron detectors, microscope technology and software provided the stimulus for a `quantum leap' in the application of cryo‐electron microscopy in structural biology, and many national and international centres have since been created in order to exploit this. Here, a new facility for cryo‐electron microscopy focused on single‐particle reconstruction of biological macromolecules that has been commissioned at the European Synchrotron Radiation Facility (ESRF) is presented. The facility is operated by a consortium of institutes co‐located on the European Photon and Neutron Campus and is managed in a similar fashion to a synchrotron X‐ray beamline. It has been open to the ESRF structural biology user community since November 2017 and will remain open during the 2019 ESRF–EBS shutdown.