Premium
1.8 Å resolution crystal structure of the carbapenem intrinsic resistance protein CarF
Author(s) -
Tichy Evelyn M.,
Hardwick Steven W.,
Luisi Ben F.,
Salmond George P. C.
Publication year - 2017
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.374
H-Index - 138
ISSN - 2059-7983
DOI - 10.1107/s2059798317002236
Subject(s) - chemistry , bacteria , antibiotics , enzyme , antibiotic resistance , protein structure , computational biology , biochemistry , microbiology and biotechnology , biology , genetics
The natural production of the β‐lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self‐intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived.