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Frequency distribution of space groups in soluble and membrane proteins and their complexes
Author(s) -
Gaur Rajneesh K.
Publication year - 2021
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 37
ISSN - 2053-230X
DOI - 10.1107/s2053230x21005719
Subject(s) - oligomer , distribution (mathematics) , space (punctuation) , chemistry , monomer , membrane protein , group (periodic table) , membrane , crystallography , mathematics , biochemistry , polymer , mathematical analysis , computer science , organic chemistry , operating system
The space‐group frequency distributions for two types of proteins and their complexes are explored. Based on the incremental availability of data in the Protein Data Bank, an analytical assessment shows a preferential distribution of three space groups, i.e. P 2 1 2 1 2 1 > P 12 1 1 > C 121, in soluble and membrane proteins as well as in their complexes. In membrane proteins, the order of the three space groups is P 2 1 2 1 2 1 > C 121 > P 12 1 1. The distribution of these space groups also shows the same pattern whether a protein crystallizes with a monomer or an oligomer in the asymmetric unit. The results also indicate that the sizes of the two entities in the structures of soluble proteins crystallized as complexes do not influence the frequency distribution of space groups. In general, it can be concluded that the space‐group frequency distribution is homogenous across different types of proteins and their complexes.