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Crystal structure of Arabidopsis thaliana peroxiredoxin A C119S mutant
Author(s) -
Yang Ye,
Cai Wenguang,
Wang Junchao,
Pan Weimin,
Liu Lin,
Wang Mingzhu,
Zhang Min
Publication year - 2018
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 37
ISSN - 2053-230X
DOI - 10.1107/s2053230x18010920
Subject(s) - peroxiredoxin , arabidopsis thaliana , mutant , arabidopsis , chloroplast , chemistry , biology , biochemistry , enzyme , gene , peroxidase
Peroxiredoxins (Prxs), a large family of antioxidant enzymes, are abundant in all living organisms. Peroxiredoxin A (PrxA) from Arabidopsis thaliana belongs to the typical 2‐Cys Prx family and is localized in the chloroplast. This article reports the crystal structure of a PrxA C119S mutant refined to 2.6 Å resolution. The protein exists as a decamer both in the crystal structure and in solution. The structure is in the reduced state suitable for the approach of peroxide, though conformational changes are needed for the resolving process.