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Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis
Author(s) -
Kumar Adarsh,
Karthikeyan Subramanian
Publication year - 2018
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 37
ISSN - 2053-230X
DOI - 10.1107/s2053230x18002236
Subject(s) - biology , mycobacterium smegmatis , gene , crystal structure , genetics , crystallography , chemistry , tuberculosis , mycobacterium tuberculosis , medicine , pathology
The MSMEG_4306 gene from Mycobacterium smegmatis encodes a protein of unknown function with 242 amino‐acid residues that contains a conserved zinc‐ribbon domain at its C‐terminus. Here, the crystal structure of MSMEG_4306 determined by the single‐wavelength anomalous dispersion method using just one zinc ion co‐purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled‐coil helix domain in the N‐terminal region and a zinc‐ribbon domain in the C‐terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from Chlamydia trachomatis and HP0958 from Helicobacter pylori , although they share only ∼15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids.

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