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1.25 Å resolution structure of an RNA 20‐mer that binds to the TREX2 complex
Author(s) -
Valkov Eugene,
Stewart Murray
Publication year - 2015
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 37
ISSN - 2053-230X
DOI - 10.1107/s2053230x1501643x
Subject(s) - antiparallel (mathematics) , duplex (building) , speed wobble , crystallography , wobble base pair , nucleotide , rna , crystal structure , base pair , ribonucleotide , chemistry , stereochemistry , physics , dna , transfer rna , biochemistry , classical mechanics , quantum mechanics , magnetic field , gene
The 1.25 Å resolution H 32: R crystal structure of a 20 nt ribonucleotide that binds to the TREX‐2 complex with high affinity shows a double‐stranded RNA duplex arranged along a crystallographic 3 1 axis in which the antiparallel chains overlap by 18 nucleotides and are related by a crystallographic twofold axis. The duplex shows C–A, U–U and C–C noncanonical base pairings together with canonical Watson–Crick A–U and G–C pairs and a G–U wobble.