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Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis
Author(s) -
Gao YunRong,
Feng Na,
Chen Tao,
Li DeFeng,
Bi LiJun
Publication year - 2015
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 37
ISSN - 2053-230X
DOI - 10.1107/s2053230x15007281
Subject(s) - mycobacterium tuberculosis , isoelectric point , protein subunit , protein family , resolution (logic) , chemistry , crystallography , amino acid , domain (mathematical analysis) , biology , tuberculosis , genetics , biochemistry , gene , mathematics , medicine , computer science , pathology , artificial intelligence , enzyme , mathematical analysis
Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P 1, with unit‐cell parameters a = 54.97, b = 69.60, c = 70.32 Å, α = 103.71, β = 111.06, γ = 105.83°. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 Å with an R cryst and R free of 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix–turn–helix domain connected to an α‐helical dimerization domain.