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Structures and binding specificity of galactose‐ and mannose‐binding lectins from champedak: differences from jackfruit lectins
Author(s) -
Gabrielsen Mads,
AbdulRahman Puteri Shafinaz,
Othman Shatrah,
Hashim Onn H.,
Cogdell Richard J.
Publication year - 2014
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 37
ISSN - 2053-230X
DOI - 10.1107/s2053230x14008966
Subject(s) - mannose , galactose , lectin , mannan binding lectin , biochemistry , binding selectivity , sugar , plasma protein binding , biology , chemistry , computational biology
Galactose‐binding and mannose‐binding lectins from the champedak fruit, which is native to South‐east Asia, exhibit useful potential clinical applications. The specificity of the two lectins for their respective ligands allows the detection of potential cancer biomarkers and monitoring of the glycosylated state of proteins in human serum and/or urine. To fully understand and expand the use of these natural proteins, their complete sequences and crystal structures are presented here, together with details of sugar binding.