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Two new zinc(II) and mercury(II) complexes based on N , N ′‐(cyclohexane‐1,2‐diylidene)bis(4‐fluorobenzohydrazide): synthesis, crystal structures and antibacterial activities
Author(s) -
OmarAli Al-Ameen Bariz,
Al-Karawi Ahmed Jasim M.,
Awad Adil A.,
Dege Necmi,
Kansız Sevgi,
Agar Erbil,
Hussein Zaman Ahmed,
Mohammed Iman Rajab
Publication year - 2020
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229620004994
Subject(s) - cyclohexane , chemistry , zinc , crystal structure , antibacterial activity , nuclear chemistry , crystallography , ligand (biochemistry) , tetrahedral molecular geometry , metal , chloride , single crystal , stereochemistry , medicinal chemistry , bacteria , organic chemistry , biochemistry , receptor , biology , genetics
Reaction of N , N ′‐(cyclohexane‐1,2‐diylidene)bis(4‐fluorobenzohydrazide), C 20 H 18 F 2 N 4 O 2 , ( L F ), with zinc chloride and mercury(II) chloride produced different types and shapes of neutral coordination complexes, namely, dichlorido[ N , N ′‐(cyclohexane‐1,2‐diylidene)bis(4‐fluorobenzohydrazide)‐κ 2 N , O ]zinc(II), [ZnCl 2 (C 20 H 18 F 2 N 4 O 2 )], ( 1 ), and dichlorido[ N , N ′‐(cyclohexane‐1,2‐diylidene)bis(4‐fluorobenzohydrazide)‐κ 4 O , N , N ′, O ′]mercury(II), [HgCl 2 (C 20 H 18 F 2 N 4 O 2 )], ( 2 ). The organic ligand and its metal complexes are characterized using various techniques: IR, UV–Vis and nuclear magnetic resonance (NMR) spectroscopies, in addition to powder X‐ray diffraction (PXRD), single‐crystal X‐ray crystallography and microelemental analysis. Depending upon the data from these analyses and measurements, a typical tetrahedral geometry was confirmed for zinc complex ( 1 ), in which the Zn II atom is located outside the bis(benzhydrazone) core. The Hg II atom in ( 2 ) is found within the core and has a common octahedral structure. The in vitro antibacterial activities of the prepared compounds were evaluated against two different bacterial strains, i.e. gram positive Bacillus subtilis and gram negative Pseudomonas aeruginosa bacteria. The prepared compounds exhibited differentiated growth‐inhibitory activities against these two bacterial strains based on the difference in their lipophilic nature and structural features.