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Dinuclear cobalt and nickel complexes of a mercaptoacetic acid substituted 1,2,4‐triazole ligand: syntheses, structures and urease inhibitory studies
Author(s) -
Fang Zi-Yi,
Zhang Li,
Ma Jian-Ping,
Zhao Long,
Wang Shi-Ling,
Xie Nan-Hua,
Liu Yi-Qin,
Guo Xiao-Ying,
Qin Jie
Publication year - 2019
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229619015602
Subject(s) - cobalt , nickel , urease , chemistry , ligand (biochemistry) , triazole , stereochemistry , combinatorial chemistry , 1,2,4 triazole , inhibitory postsynaptic potential , medicinal chemistry , enzyme , biochemistry , organic chemistry , receptor , biology , neuroscience
Because of its versatile coordination modes and strong coordination ability, the mercaptoacetic acid substituted 1,2,4‐triazole 2‐{[5‐(pyridin‐2‐yl)‐4 H ‐1,2,4‐triazol‐3‐yl]sulfanyl}acetic acid ( H 2 L ) was synthesized and characterized. Treatment of H 2 L with cobalt and nickel acetate afforded the dinuclear complexes {μ‐3‐[(carboxylatomethyl)sulfanyl]‐5‐(pyridin‐2‐yl)‐4 H ‐1,2,4‐triazol‐4‐ido‐κ 2 N 1 , N 5 : N 2 , O }bis[aqua(methanol‐κ O )cobalt(II)] methanol disolvate, [Co 2 (C 9 H 6 N 4 O 2 S) 2 (CH 3 OH) 2 (H 2 O) 2 ]·2CH 3 OH ( 1 ), and {μ‐3‐[(carboxylatomethyl)sulfanyl]‐5‐(pyridin‐2‐yl)‐4 H ‐1,2,4‐triazol‐4‐ido‐κ 2 N 1 , N 5 : N 2 , O }bis[diaquanickel(II)] methanol disolvate dihydrate, [Ni 2 (C 9 H 6 N 4 O 2 S) 2 (H 2 O) 4 ]·2CH 3 OH·2H 2 O ( 2 ), respectively. Complex 1 crystallized in the monoclinic space group P 2 1 / c , while 2 crystallized in the tetragonal space group I 4 1 / a . Single‐crystal X‐ray diffraction studies revealed that H 2 L is doubly deprotonated and acts as a tetradentate bridging ligand in complexes 1 and 2 . For both of the obtained complexes, extensive hydrogen‐bond interactions contribute to the formation of their three‐dimensional supermolecular structures. Hirshfeld surface analysis was used to illustrate the intermolecular interactions. Additionally, the urease inhibitory activities of 1 , 2 and H 2 L were investigated against jack bean urease, where the two complexes revealed strong urease inhibition activities.