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Crystal structure and energetic features of the cocrystal of carbamazepine with 3,5‐dinitrobenzoic acid
Author(s) -
Pawlędzio Sylwia,
Trzybiński Damian,
Woźniak Krzysztof
Publication year - 2019
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229619009896
Subject(s) - cocrystal , hydrogen bond , molecule , crystal structure , crystallography , intermolecular force , crystal structure prediction , crystal (programming language) , lattice energy , supramolecular chemistry , chemistry , stereochemistry , organic chemistry , computer science , programming language
The synthesis and detailed description of the crystal structure and energetic features of the 1:1 cocrystal of carbamazepine (5 H ‐dibenzo[ b , f ]azepine‐5‐carboxamide, CBZ ) with 3,5‐dinitrobenzoic acid ( 35DNBA ), i.e. C 15 H 12 N 2 O·C 7 H 4 N 2 O 6 , are reported. The CBZ and 35DNBA molecules are packed in alternately arranged layers. Two characteristic R 2 2 (8) and R 2 2 (16) hydrogen‐bond ring motifs have been found. The supramolecular architecture, besides the network of hydrogen bonds, is also stabilized by numerous C—H…π, C=O…π, N—O…π, N—O…C and C=O…N weak intermolecular contacts involving neighbouring molecules in the crystal network. Identified interactions have been discussed in detail on the basis of a structural and energetic analysis. The latter approach, performed using the Pixel and CrystalExplorer programs, yielded additional information about the lattice energy and energetic landscape of the respective interactions in the crystal of CBZ·3DNBA with the evaluation of electrostatic, polarization, repulsion and dispersion terms.