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Polymorphic modifications of a 1 H ‐pyrrolo[3,2,1‐ ij ]quinoline‐5‐carboxamide possessing strong diuretic properties
Author(s) -
Shishkina Svitlana V.,
Levandovskiy Igor A.,
Ukrainets Igor V.,
Sidorenko Lyudmila V.,
Grinevich Lina A.,
Yanchuk Igor B.
Publication year - 2018
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229618016352
Subject(s) - triclinic crystal system , monoclinic crystal system , quinoline , crystallography , molecule , crystal structure , carboxamide , chemistry , stereochemistry , organic chemistry
6‐Hydroxy‐ N ‐(4‐methoxyphenyl)‐4‐oxo‐2,4‐dihydro‐1 H ‐pyrrolo[3,2,1‐ ij ]quinoline‐5‐carboxamide, C 19 H 16 N 2 O 4 , possesses strong diuretic properties and can be used as a new hypertension remedy. Two polymorphic modifications of this compound have been found, namely the triclinic polymorph (space group P ), with one molecule in the asymmetric unit, and the monoclinic polymorph (space group P 2 1 / n ), with two molecules in asymmetric unit. An analysis of the pairwise interaction energies between the molecules in the crystal phase revealed differences in the crystal packing. The triclinic form has only one level of organization, namely a chain/column, while the monoclinic form has two levels of organization, with a chain/column as the primary basic structural motif and a layer as the secondary basic structural motif.