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Crystal structure and sequential dehydration transitions of disodium guanosine 5′‐monophosphate tetrahydrate
Author(s) -
Tsubonoya Masaaki,
Murofushi Akitaka,
Yamamura Shigefumi,
Sugawara Yoko
Publication year - 2018
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229618012639
Subject(s) - tetrahydrate , guanosine , chemistry , crystallography , dehydration , crystal (programming language) , moiety , crystal structure , ribose , deoxyguanosine , stereochemistry , organic chemistry , biochemistry , enzyme , computer science , programming language , adduct
Disodium guanosine 5′‐monophosphate was reported previously to crystallize as both the tetrahydrate and the heptahydrate. We herein report a determination of the molecular and crystal structures of the title tetrahydrated salt, 2Na + ·C 10 H 12 N 5 O 8 P 2− ·4H 2 O. It was found that the structure differs markedly from that of the heptahydrate, but greatly resembles that of disodium deoxyguanosine 5′‐monophosphate tetrahydrate. The C2′—O2′H moiety of ribose is surrounded by hydrophilic moieties and is disordered over two sites. The sugar puckering mode is O4′‐ endo ‐C1′‐ exo at both sites and the conformation around the C4′—C5′ bond is gauche–trans . Powder X‐ray diffraction and thermal analyses revealed that the temperature‐controlled transition from the tetrahydrate to the anhydride proceeded through three intermediate phases between 40 and 60 °C at 0% relative humidity. Large induction periods were observed.