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Synthesis, structure and in vitro cytotoxicity of platinum(II) complexes containing eugenol and a quinolin‐8‐ol‐derived chelator
Author(s) -
Nguyen Thi Thanh Chi,
Truong Thi Cam Mai,
Pham Van Thong,
Nguyen Long,
Nguyen Ha My,
Van Meervelt Luc
Publication year - 2017
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229617015200
Subject(s) - cytotoxicity , eugenol , in vitro , platinum , chelation , chemistry , platinum compounds , combinatorial chemistry , pharmacology , stereochemistry , biochemistry , organic chemistry , biology , catalysis
The synthesis of potassium (η 2 ‐4‐allyl‐2‐methoxyphenol)trichloridoplatinate(II), K[PtCl 3 (C 10 H 12 O 2 )], ( 1 ), starting from Zeise's salt and Ocimum sanctum L. oil has been optimized. Starting from ( 1 ), three new platinum(II) complexes, namely (η 2 ‐4‐allyl‐2‐methoxyphenol)chlorido(2‐methylquinolin‐8‐olato‐κ 2 N , O )platinum(II), ( 2 ), (η 2 ‐4‐allyl‐2‐methoxyphenol)chlorido(5‐nitroquinolin‐8‐olato‐κ 2 N , O )platinum(II), ( 3 ), and (η 2 ‐4‐allyl‐2‐methoxyphenol)chlorido(5,7‐dichloroquinolin‐8‐olato‐κ 2 N , O )platinum(II), [Pt(C 9 H 4 Cl 2 NO)Cl(C 10 H 12 O 2 )], ( 4 ), containing eugenol and a quinolin‐8‐ol derivative (R‐OQ), have been synthesized and characterized by elemental analyses, MS, IR, 1 H NMR and NOESY spectra. For ( 1 ) and ( 4 ), single‐crystal X‐ray diffraction studies were also carried out. Complexes ( 2 )–( 4 ) show good inhibiting abilities on three human cancer cell lines, i.e. KB, Hep‐G2 and LU, with IC 50 values of 1.42–17.8 µ M . Complex ( 3 ) gives an impressively high activity against KB, Hep‐G2, LU and MCF‐7, with IC 50 values of 1.42–4.91 µ M , which are much lower than those of cisplatin and some other platinum(II) complexes.