Premium
Planarity of benzoylthiocarbazate tuberculostatics. IV. Polymorphs of N ′‐(1,3‐dithiolan‐2‐ylidene)‐4‐nitrobenzohydrazide
Author(s) -
Szczesio Małgorzata,
Olczak Andrzej,
Gobis Katarzyna,
Główka Marek L.
Publication year - 2017
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229617012566
Subject(s) - planarity testing , crystallography , intermolecular force , polymorphism (computer science) , molecule , chemistry , crystal structure , mycobacterium tuberculosis , stereochemistry , diffraction , tuberculosis , physics , organic chemistry , medicine , biochemistry , pathology , genotype , gene , optics
The search for new tuberculostatics is important considering the occurrence of drug‐resistant strains of Mycobacterium tuberculosis . Three polymorphs of N ′‐(1,3‐dithiolan‐2‐ylidene)‐4‐nitrobenzohydrazide (a potentially tuberculostatic agent), C 10 H 9 N 3 O 3 S 2 , denoted (I1), (I2) and (I3), and the monohydrate of this compound, C 10 H 9 N 3 O 3 S 2 ·H 2 O, (I4), have been characterized by single‐crystal X‐ray diffraction. The conformations of the molecules in all these structures are very similar. Structures (I1), (I2) and (I3) provide an example of packing polymorphism resulting from different intermolecular interactions.