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The preparation, characterization, structure and dissolution analysis of apremilast solvatomorphs
Author(s) -
Wu Yun-Deng,
Zhang Xiao-Lei,
Liu Xiao-Hong,
Xu Jian,
Zhang Mei,
Shen Kun,
Zhang Si-Han,
He Yong-Mei,
Ma Yan,
Zhang Ai-Hua
Publication year - 2017
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229617002984
Subject(s) - apremilast , characterization (materials science) , dissolution , materials science , nanotechnology , chemical engineering , medicine , engineering , dermatology , psoriatic arthritis , psoriasis
Apremilast (AP) {systematic name: ( S )‐2‐[1‐(3‐ethoxy‐4‐methoxyphenyl)‐2‐(methylsulfonyl)ethyl]‐4‐acetamidoisoindoline‐1,3‐dione} is an inhibitor of phosphodieasterase‐4 (PDE4) and is indicated for the treatment of adult patients with active psoriatic arthritis. The ability of AP to form solvates has been investigated and three solvatomorphs of AP, namely, the AP ethyl acetate hemisolvate, C 22 H 24 N 2 O 7 S·0.5C 4 H 8 O 2 , the AP toluene hemisolvate, C 22 H 24 N 2 O 7 S·0.5C 7 H 8 , and the AP dichloromethane monosolvate, C 22 H 24 N 2 O 7 S·CH 2 Cl 2 , were obtained. The three AP solvatomorphs were characterized by X‐ray powder diffraction, thermogravimetric analysis and differential scanning calorimetry. Single‐crystal X‐ray diffraction was used to analyze the structures, crystal symmetry, packing modes, stoichiometry and hydrogen‐bonding interactions of the solvatomorphs. In addition, dissolution analyses were performed to study the dissolution rates of different AP solvatomorph tablets in vitro and to make comparisons with commercial apremilast tablets (produced by Celgene); all three solvatomorphs showed similar dissolution rates and similar values of the similarity factor f 2 in a comparison of their dissolution profiles.