Premium
A new antibacterial silver(I) complex incorporating 2,5‐dimethylpyrazine and the anti‐inflammatory diclofenac
Author(s) -
Hamamci Alisir Sevim,
Dege Necmi
Publication year - 2016
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 17
ISSN - 2053-2296
DOI - 10.1107/s2053229616017009
Subject(s) - supramolecular chemistry , ligand (biochemistry) , carboxylate , chemistry , crystal structure , stereochemistry , molecule , intramolecular force , crystallography , organic chemistry , receptor , biochemistry
Ag I ‐containing coordination complexes have attracted attention because of their photoluminescence properties and antimicrobial activities and, in principle, these properties depend on the nature of the structural topologies. A novel two‐dimensional silver(I) complex with the anti‐inflammatory diclofenac molecule, namely bis{μ‐2‐[2‐(2,6‐dichloroanilino)phenyl]acetato‐κ 3 O , O ′: O }bis(μ‐2,5‐dimethylpyrazine‐κ 2 N : N ′)silver(I), [Ag 2 (C 14 H 10 Cl 2 NO 2 ) 2 (C 6 H 8 N 2 )] n , (I), has been synthesized and characterized by single‐crystal X‐ray diffraction, revealing that the Ag I ions are chelated by the carboxylate groups of the anionic 2‐[2‐(2,6‐dichloroanilino)phenyl]acetate (dicl) ligand in a μ 3 ‐η 1 :η 2 coordination mode. Each dicl ligand links three Ag I atoms to generate a one‐dimensional infinite chain. Adjacent chains are connected through 2,5‐dimethylpyrazine (dmpyz) ligands to form a two‐dimensional layer structure parallel to the crystallographic bc plane. The layers are further connected by C—H…π interactions to generate a three‐dimensional supramolecular structure. Additionally, the most striking feature is that the structure contains an intramolecular C—H …Ag anagostic interaction. Furthermore, the title complex has been tested for its in vitro antibacterial activity and is determined to be highly effective on the studied microorganisms.